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Related Experiment Videos

Skin, immunity and the nervous system

L Misery1

  • 1Institut National de la Santé et de la Recherche Médicale (INSERM U346), Lyon, France.

The British Journal of Dermatology
|February 21, 1998
PubMed
Summary

The skin, nervous system, and immune system are interconnected, communicating via neurotransmitters and cytokines. This neuroimmunocutaneous system

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Area of Science:

  • Dermatology
  • Neuroscience
  • Immunology

Background:

  • Nerve fibers and cutaneous cells interact through neuromediators and neurohormones.
  • Skin cells secrete and respond to these signaling molecules.
  • The skin hosts immune cells that are also modulated by these neurochemicals.

Purpose of the Study:

  • To explore the intricate connections between the nervous system, skin, and immune system.
  • To introduce the concept of a coordinated neuroimmunocutaneous system.
  • To investigate the role of this system in skin disorders like psoriasis.

Main Methods:

  • Confocal microscopy.
  • Electron microscopy.

Main Results:

  • Nerve fibers in the skin secrete numerous neuromediators (e.g., substance P, acetylcholine).
  • Skin cells express receptors for these neuromediators and neurohormones.
  • The neuroimmunocutaneous system becomes destabilized in skin disorders, potentially driving inflammation.

Conclusions:

  • The skin, nervous system, and immune system are not independent but form an integrated neuroimmunocutaneous system.
  • Destabilization of this system contributes to the induction and maintenance of inflammatory skin conditions.
  • This integrated system utilizes a common language of cytokines and neurotransmitters.

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