Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autoimmune sensorineural hearing loss: a human temporal bone study

D L Hoistad1, P A Schachern, M M Paparella

  • 1Department of Otolaryngology, School of Medicine, University of Minnesota, Minneapolis, USA.

American Journal of Otolaryngology
|February 21, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The surgical challenge of carotid artery and Fallopian canal dehiscence in chronic ear disease: a pitfall for endoscopic approach.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2016
Same author

[Histopathologically observational study of cartilage-mucosa on the eustachian tube isthmus of temporal bone with otitis media].

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology·2003
Same author

The development of the middle ear in neonatal chinchillas II. Two weeks to adulthood.

Acta oto-laryngologica·2001
Same author

Pattern changes of mucin gene expression with pneumococcal otitis media.

International journal of pediatric otorhinolaryngology·2001
Same author

Wideband reflectance tympanometry in chinchillas and human.

The Journal of the Acoustical Society of America·2001
Same author

Update on conservative management of acoustic neuroma.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2001
Same journal

Re: Sarcopenia and postoperative morbidity in head and neck cancer: a systematic review and meta-analysis.

American journal of otolaryngology·2026
Same journal

Epistaxis burden in hereditary hemorrhagic telangiectasia: Validation and refinement of the NOSE-HHT.

American journal of otolaryngology·2026
Same journal

An assessment of pharmacologic deep vein thrombosis prophylaxis on head and neck free flap outcomes.

American journal of otolaryngology·2026
Same journal

Rapid improvement of nasal obstruction after treatment with a non-vasoconstrictive osmotic nasal spray: A prospective observational study.

American journal of otolaryngology·2026
Same journal

Evaluation of systemic inflammation in sinonasal inverted papilloma using hematological and biochemical markers.

American journal of otolaryngology·2026
Same journal

The impact of race and ethnicity on cochlear implant outcomes.

American journal of otolaryngology·2026
See all related articles

Histopathologic examination of temporal bones revealed significant damage, including missing organs of Corti and lymphocytic infiltration, suggesting autoimmune sensorineural hearing loss (SNHL). These findings in a patient with ulcerative colitis support the autoimmune basis of SNHL.

Area of Science:

  • Otolaryngology
  • Immunology
  • Pathology

Background:

  • Investigating the histopathologic basis of sensorineural hearing loss (SNHL) in patients with autoimmune conditions.
  • Examining temporal bones from a patient with a history of ulcerative colitis, leukemia, and SNHL.

Observation:

  • Microscopic analysis of temporal bones revealed severe cochlear damage, including absent organs of Corti.
  • Significant findings included lymphocytic infiltration in spiral ganglia and endolymphatic hydrops.
  • Fibrosis and osteoneogenesis were observed in the cochlea and vestibular structures.

Findings:

  • Complete absence of organs of Corti in all cochlear turns.
  • Reduced spiral ganglion cells with lymphocytic infiltration.
  • Endolymphatic hydrops, fibrosis, and osteoneogenesis affecting cochlear and vestibular structures.

Related Experiment Videos

  • Presence of lymphocytes in the endolymphatic sac and surrounding tissues.

    • Implications:

    • The observed histopathologic changes closely resemble findings in animal models of autoimmune inner ear disease.
    • Suggests a potential autoimmune etiology for sensorineural hearing loss and vestibular symptoms in this patient.
    • Highlights the importance of considering autoimmune mechanisms in unexplained SNHL.