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Acute hepatitis during hypersensitivity syndrome due to midecamycin
T Thevenot1, P Mathurin, F Martinez
1Service d'Hépato-Gastroentérologie, Groupe hospitalier Pitié-Salpétrière, Paris, France.
European Journal of Gastroenterology & Hepatology
|February 21, 1998
Abstract:
We report here the first case of symptomatic acute hepatic injury due to midecamycin in a 58-year-old man. The clinical picture was compatible with a hypersensitivity syndrome with cutaneous, renal and hepatic involvement. Liver eosinophil polynuclear infiltrate, hypereosinophilia and acute interstitial nephritis were consistent with the hypothesis of an immunoallergic mechanism.