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Related Experiment Videos

Fluoxetine and premature ejaculation: a double-blind, crossover, placebo-controlled study

S M Haensel1, T M Klem, W C Hop

  • 1Department of Endocrinology and Reproduction, Erasmus University and Dijkzigt Academic Hospital, Rotterdam, The Netherlands. shaensel@euronet.nl

Journal of Clinical Psychopharmacology
|February 24, 1998
PubMed
Summary

This study found that fluoxetine effectively increased ejaculation latency in men with premature ejaculation (PE) and combined PE with erectile dysfunction (ED). The medication also improved objective erectile response without significant side effects.

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Area of Science:

  • Pharmacology
  • Sexual Medicine
  • Clinical Trials

Background:

  • Premature ejaculation (PE) and erectile dysfunction (ED) are common male sexual dysfunctions.
  • Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are sometimes used off-label for PE.
  • The efficacy and safety of low-dose fluoxetine for these conditions require further investigation.

Purpose of the Study:

  • To evaluate the effects of fluoxetine on sexual function, specifically ejaculation latency and erectile response, in men with PE and/or ED.
  • To compare fluoxetine's effects against a placebo in a controlled crossover study design.

Main Methods:

  • A prospective, double-blind, placebo-controlled, crossover study involving four groups: PE, PE/ED, ED, and healthy controls.
  • Subjects received fluoxetine (5-10 mg/day) or placebo for 4-week periods, separated by washout phases.

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  • Evaluations included laboratory assessments of sexual function and home-based daily logs and nocturnal penile tumescence monitoring.

    • Main Results:

    • Fluoxetine significantly increased ejaculation latency in the combined PE and PE/ED groups (p = 0.007).
    • A significant increase in ejaculation latency was observed in the PE/ED group (p = 0.03).
    • Objective erectile response improved in all groups during laboratory assessment, though subjective effects were not significant. No major adverse events were reported.

    Conclusions:

    • Low-dose fluoxetine (5-10 mg/day) is effective in increasing ejaculation latency for men with premature ejaculation.
    • Fluoxetine demonstrates potential as a treatment for PE, with improvements in objective erectile function noted.
    • The study supports the use of fluoxetine for managing premature ejaculation, particularly when co-occurring with erectile dysfunction.