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Chronic recurrent multifocal osteomyelitis associated with Crohn's disease
1Internal Medicine Department, VA Medical Center, Emory University Hospital, Atlanta, Georgia, USA.
The American Journal of the Medical Sciences
|February 24, 1998
Summary
Chronic recurrent multifocal osteomyelitis (CRMO), a rare inflammatory bone condition, can occur with Crohn's disease. This case report details the first instance of CRMO in an adult with Crohn's disease, notably without typical SAPHO syndrome features.
Area of Science:
- Rheumatology
- Gastroenterology
- Pediatric Osteology
Background:
- Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, non-infectious inflammatory bone disorder.
- CRMO typically affects children and adolescents, presenting as recurrent bone lesions.
- Associations with psoriasis, palmoplantar pustulosis, and SAPHO syndrome are documented.
Purpose of the Study:
- To report the first case of CRMO coexisting with Crohn's disease in an adult.
- To highlight a CRMO presentation without pustular lesions or other SAPHO syndrome features.
Main Methods:
- Case report presentation.
- Review of patient's clinical history, imaging, and laboratory findings.
- Literature review for similar cases.
Main Results:
- A 49-year-old male patient presented with CRMO and coexisting Crohn's disease.
- The patient's CRMO did not exhibit pustular skin lesions or other characteristic SAPHO syndrome manifestations.
- This represents a novel association in adult CRMO.
Conclusions:
- CRMO can occur in adults with inflammatory bowel disease, such as Crohn's disease.
- The absence of typical SAPHO syndrome features in this CRMO case broadens the clinical spectrum of the condition.
- Further research is warranted to understand the relationship between CRMO and Crohn's disease.