Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Videofetoscopically assisted fetal tissue engineering: bladder augmentation

D O Fauza1, S J Fishman, K Mehegan

  • 1Harvard Center for Minimally Invasive Surgery and the Department of Surgery, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Journal of Pediatric Surgery
|February 24, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perinatal outcomes following intrauterine transfusion for fetal anemia secondary to fetal or placental tumor: systematic review.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2026
Same author

Comparison of urology residency training between the United States and China.

Actas urologicas espanolas·2022
Same author

Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo.

Journal of biomedical materials research. Part B, Applied biomaterials·2015
Same author

Assessments of injectable alginate particle-embedded fibrin hydrogels for soft tissue reconstruction.

Biomedical materials (Bristol, England)·2013
Same author

Decellularization for whole organ bioengineering.

Biomedical materials (Bristol, England)·2013
Same author

Controlled heparin conjugation on electrospun poly(ε-caprolactone)/gelatin fibers for morphology-dependent protein delivery and enhanced cellular affinity.

Acta biomaterialia·2012
Same journal

Reimagining the Surgical Safety Checklist Through a Pediatric Lens.

Journal of pediatric surgery·2026
Same journal

Bridge Fixation Provides Consistent Implant Stability Across Surgical Techniques: A Multicenter Study.

Journal of pediatric surgery·2026
Same journal

National Benchmarks for Penetrating Head Injury in U.S. Children and Adolescents: Mechanism, Intent, and Disparities in Mortality.

Journal of pediatric surgery·2026
Same journal

Long-Term Growth and Neurodevelopmental Outcomes of a Standardized Gastroschisis Feeding Protocol: a retrospective cohort study.

Journal of pediatric surgery·2026
Same journal

Economic Evaluation of Hirschsprung Disease Testing Strategies for Children with Medically-Refractory Chronic Constipation: A Cost-Effectiveness Analysis.

Journal of pediatric surgery·2026
Same journal

Preoperative underweight is associated with a more complicated perioperative course and impairs recovery in Hirschsprung's disease: The pivotal role of weight-for-age z-score.

Journal of pediatric surgery·2026
See all related articles

Fetal bladder tissue engineering using videofetoscopy provides autologous tissue for neonatal reconstruction. Engineered bladders demonstrated improved compliance and capacity, offering a viable solution for congenital anomalies.

Area of Science:

  • Regenerative Medicine
  • Fetal Surgery
  • Biomaterials

Background:

  • Congenital anomalies often require surgical reconstruction in newborns.
  • Limited tissue availability in neonates hinders surgical repair.
  • Fetal tissue engineering offers a solution for creating autologous tissue in utero.

Purpose of the Study:

  • To investigate the feasibility of fetal bladder tissue engineering for neonatal reconstruction.
  • To assess the efficacy of using autologous, expanded fetal bladder tissue for surgical augmentation.
  • To evaluate the urodynamic and histological characteristics of engineered bladders.

Main Methods:

  • Bladder exstrophy was created in fetal lambs.
  • Minimally invasive videofetoscopic harvest of fetal bladder tissue.

Related Experiment Videos

  • In vitro cultivation and expansion of urothelial and smooth muscle cells.
  • Seeding cells onto a biodegradable scaffold prior to delivery.
  • Surgical augmentation of exstrophic bladders with engineered tissue post-delivery.

    • Main Results:

    • 100% fetal survival rate; 90% survival post-implantation.
    • Engineered bladders showed significantly greater compliance and capacity compared to primary closure.
    • Histological analysis confirmed a multilayered urothelial lining and smooth muscle layers.
    • No major complications observed in the engineered tissue group.

    Conclusions:

    • Videofetoscopically assisted fetal bladder engineering is a viable approach for neonatal reconstruction.
    • Autologous engineered fetal bladder tissue closely mimics native bladder architecture.
    • This technique holds promise for treating human neonatal conditions like bladder exstrophy.