Gammadelta T cells in host defense and epithelial cell biology

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  • 1The Scripps Research Institute, La Jolla, California 92037, USA.

Clinical Immunology and Immunopathology
|March 7, 1998
PubMed

Recent studies have demonstrated increased numbers of gammadelta T cells in a variety of human infectious as well as noninfectious diseases. In some cases gammadelta T cells could be shown to destroy infected or transformed cells. Advances in the identification of ligands recognized by gammadelta T cells and the development of animal model systems to study these cells in vivo should overcome some of the major obstacles currently preventing a better understanding of gammadelta T cell function in immune responses. As we gain this knowledge it may become possible to design therapeutic strategies exploiting unique properties of gammadelta T cells to promote more effective immunity.

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