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Related Experiment Videos

Functional redundancy and gustatory development in bdnf null mutant mice

Cooper1, Oakley

  • 1Department of Biology, University of Michigan, Ann Arbor, MI 48109-1048, USA

Brain Research. Developmental Brain Research
|February 25, 1998
PubMed
Summary
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Brain-derived neurotrophic factor (BDNF) is crucial for taste neuron survival and taste bud formation. Redundant factors likely rescue surviving neurons locally within the gustatory epithelium.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Sensory Biology

Background:

  • Taste bud development relies on taste neuron survival.
  • Brain-derived neurotrophic factor (BDNF) plays a key role in taste neuron development.

Purpose of the Study:

  • To identify the source of a rescue factor for taste neurons lacking BDNF.
  • To understand the mechanism of functional redundancy in gustatory innervation.

Main Methods:

  • Studied taste bud formation in mice with a null mutation for BDNF.
  • Assessed taste bud abundance as an indicator of taste neuron survival.
  • Analyzed variability in taste bud development across different papillae.

Main Results:

  • BDNF deficiency led to significant taste neuron death and impaired taste bud formation.

Related Experiment Videos

  • A variable number of taste neurons survived, indicating functional redundancy.
  • Independent variation in innervation across papillae suggested local rescue factors.

    • Conclusions:

    • Surviving taste neurons in BDNF-deficient mice were likely rescued by local factors in the gustatory epithelium.
    • This challenges the notion that target tissues supply only a single neurotrophic factor for sensory neurons.
    • Findings suggest a broader role for redundant neurotrophic support in sensory system development.