[Effect of angiotensin II on hemodynamics during systemic and portal administration]

The authors studied changes in the general hemodynamics in healthy nonanesthetized dogs in infusion of 27/ng/kg/min of angiotensin II into the superior vena cava and the portal vein. Portal infusion of the peptide produced a less pronounced pressor effect. Elevation of arterial pressure in systemic infusion of angiotension occurred on account of increase in the peripheral vascular resistance with decrease of minute circulation volume. In portal infusion of the preparation elevation of arterial pressure was mainly due to increase of the minute circulation volume. Differences in hemodynamic reactions could not be attributed only to the peptide metabolization in the liver. It is possible that depressor agents entered the blood from the liver in portal angiotensin II infusion.