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The aged suprachiasmatic nucleus is phase-shifted by cAMP in vitro
N F Ruby1, D M Edgar, H C Heller
1Department of Biological Sciences, Stanford University, CA 94305, USA. ruby@leland.stanford.edu
Brain Research
|February 25, 1998
Abstract:
The cyclic adenosine monophosphate (cAMP) analog, 8-bromo-cAMP, phase advanced circadian neuronal rhythms in both aged and adult rat suprachiasmatic nuclei (SCN) by approximately 2 h in vitro. Rhythm amplitude was 20% lower in aged compared to adult SCN. The diminished efficacy of serotonergic agonists to phase shift behavioral rhythms of aged animals may be due to decrements in signal transduction mechanisms proximal to cAMP.