Related Experiment Videos
Nicotinic alpha 7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage
S Shimohama1, D L Greenwald, D H Shafron
1Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
Brain Research
|February 25, 1998
Abstract:
The alpha7 receptor agonist dimethoxybenzylidene anabaseine (DMXB) protected rat neocortical neurons against excitotoxicity administered 24 h before, but not concomitantly with, NMDA. This action was blocked by nicotinic but not muscarinic antagonists. DMXB (1 mg/kg i.p.) also reduced infarct size in rats when injected 24 h before, but not during, focal ischemic insults. In a mecamylamine-sensitive manner, alpha7 receptors appear neuroprotective in non-apoptotic model.