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Related Experiment Videos

Morbidity in Turner syndrome

C H Gravholt1, S Juul, R W Naeraa

  • 1Medical Department M (Endocrinology and Diabetes), Aarhus Kommunehospital, Denmark.

Journal of Clinical Epidemiology
|February 25, 1998
PubMed
Summary
This summary is machine-generated.

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Women with Turner syndrome face higher risks of fractures, diabetes mellitus (both NIDDM and IDDM), and cardiovascular issues like hypertension and stroke. Cancer risk, excluding large bowel cancer, appears unchanged.

Area of Science:

  • Endocrinology
  • Genetics
  • Public Health

Background:

  • Turner syndrome affects 50 per 100,000 females, characterized by growth retardation, gonadal dysgenesis, and infertility.
  • Focus has been on growth, with less known about adult morbidity and natural disease course.

Purpose of the Study:

  • To assess the incidence of various diseases in women with Turner syndrome.
  • To evaluate morbidity patterns and their contribution to decreased lifespan.

Main Methods:

  • Utilized data from the Danish Cytogenetic Central Register and National Registry of Patients.
  • Analyzed morbidity data for women in Denmark from 1984 to 1993.

Main Results:

  • Confirmed increased morbidity, including fractures (osteoporotic and non-osteoporotic) and markedly increased incidence of diabetes mellitus (NIDDM, IDDM).

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  • Observed higher rates of ischemic heart disease, hypertension, and stroke.
  • Found no elevated cancer risk, except for large bowel cancer.
  • Highlighted predisposition to metabolic syndrome components (hypertension, dyslipidemia, NIDDM, obesity, hyperinsulinemia, hyperuricemia).

    • Conclusions:

    • Turner syndrome is associated with significantly increased morbidity, particularly fractures, diabetes, and cardiovascular diseases.
    • These comorbidities likely contribute to the reduced lifespan observed in Turner syndrome patients.
    • Patients with Turner syndrome exhibit a strong predisposition to metabolic syndrome abnormalities.