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Related Experiment Videos

Multidrug-resistant gram-positive pathogens. An update on current microbiological patterns

A Marchese1, E A Debbia, D Bacca

  • 1Institute of Microbiology, School of Medicine, University of Genoa, Italy.

Drugs
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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Glycopeptide resistance in enterococci is emerging in Europe. This survey found teicoplanin more active than vancomycin against enterococci and streptococci, with similar potency against staphylococci.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Gram-positive pathogens show resistance to various antibiotics, but glycopeptides were largely unaffected.
  • Emergence of glycopeptide resistance in enterococci, particularly noted in the USA, prompted a European surveillance study.

Purpose of the Study:

  • To assess the microbiological quality assurance of laboratories in identifying strains and determining glycopeptide susceptibility.
  • To determine the prevalence of glycopeptide resistance in staphylococci, streptococci, and enterococci across European hospitals.

Main Methods:

  • A European surveillance study involving 70 microbiological centers in 9 countries during 1995.
  • Utilized the National Committee for Clinical Laboratory Standards (NCCLS) agar dilution reference method for retesting 96% of 7078 Gram-positive isolates.

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  • Assessed in vitro activity of antibiotics on strains from Italian centers.

    • Main Results:

    • Teicoplanin and vancomycin showed similar activity against Staphylococcus aureus, but teicoplanin had a wider MIC range against coagulase-negative staphylococci.
    • Teicoplanin was four times more active than vancomycin against Enterococcus spp. and Streptococcus spp.
    • Enterococci exhibited the highest glycopeptide resistance, with Enterococcus faecium showing approximately 10 times more resistance than E. faecalis. Italian isolate resistance was lower than the European average.

    Conclusions:

    • Teicoplanin demonstrates superior in vitro activity compared to vancomycin against enterococci and streptococci.
    • Both teicoplanin and vancomycin exhibit similar potency against staphylococci.
    • The study highlights the need for ongoing surveillance of glycopeptide resistance in European hospitals.