Inhibition of microsomal activation of aflatoxin B1 by 3-dehydroretinol and 3-dehydroretinyl palmitate
Related Experiment Video
Updated: Oct 30, 2026
Inhibition of Aspergillus flavus Growth and Aflatoxin Production in Transgenic Maize Expressing the α-amylase Inhibitor from Lablab purpureus L.
Published on: February 15, 2019
V S Aboobaker1, N Sarma, U C Goswami
1Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
Abstract:
Two vitamin A2 compounds (3-dehydroretinol and 3-dehydroretinyl palmitate) which are predominantly present in fresh water fish have been found to be very effective in inhibiting the microsome catalysed formation of DNA adduct by the carcinogen aflatoxin B1. The inhibition appears to be due to modulation of microsomal enzymes which activate the carcinogen. Such inhibition may suggest a potential chemopreventive role of these compounds against carcinogenesis induced by aflatoxin B1.