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Single-agent therapy for nonmetastatic and low-risk gestational trophoblastic disease
1Department of Obstetrics and Gynecology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina, USA. homesley@nr.infininet.net
Objective:
To assess the effectiveness of single-agent chemotherapy in the treatment of nonmetastatic and low-risk metastatic gestational trophoblastic tumors.
Study Design:
The medical literature was reviewed concerning single-agent chemotherapy in the treatment of nonmetastatic and low-risk metastatic gestational trophoblastic tumors.
Results:
Methotrexate and actinomycin-D have achieved excellent and comparable remission rates with acceptable levels of toxicity.
Conclusion:
The optimal single-agent chemotherapy for nonmetastatic and low-risk metastatic gestational trophoblastic tumors has not yet been identified and can be best determined through a prospective, randomized trial.