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Outcome of pregnancies in women with uterine duplication anomalies
M J Cooney1, C B Benson, P M Doubilet
1Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Purpose:
This study was conducted to compare pregnancy outcomes in women with uterine duplication anomalies with outcomes in women with normal uteri.
Methods:
We studied 22 women with uterine duplication anomalies in whom first-trimester sonography demonstrated a live fetus and compared pregnancy outcomes in these patients with outcomes in 66 women with normal-appearing uteri (controls). The 2 groups were matched for gestational age at the time of first-trimester sonography.
Results:
Uterine duplication anomalies were associated with a higher miscarriage rate than were normal-appearing uteri (23% versus 6%, p < 0.05, Fisher's exact test). Deliveries resulting in liveborn infants occurred earlier in women with anomalous uteri. The mean gestational age at delivery was 37.0 weeks for women with duplication anomalies versus 38.8 weeks for controls (p < 0.05, Student's t-test), and a higher percentage of duplication anomaly patients delivered before 34 weeks' gestation (29% versus 3%, p < 0.01, Fisher's exact test). Neonates born from anomalous uteri had lower mean birth-weight percentiles than did neonates in the control group (51st versus 68th percentile, p < 0.05, t-test). There was no difference in Apgar scores between the 2 groups at 1 and 5 minutes.
Conclusions:
Women with duplication anomalies of the uterus have a higher miscarriage rate, deliver earlier, and have infants with lower birth-weight percentiles than do women with normal-appearing uteri.