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Thymic carcinoma: current staging does not predict prognosis

D Blumberg1, M E Burt, M S Bains

  • 1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

The Journal of Thoracic and Cardiovascular Surgery
|February 25, 1998
PubMed
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Thymic carcinoma patients face high recurrence rates. Innominate vessel invasion significantly predicts poor prognosis, while Masaoka staging is not useful for this cancer.

Area of Science:

  • Thoracic oncology
  • Surgical pathology

Background:

  • Thymic carcinomas are staged using Masaoka classification, originally for thymomas.
  • Prognostic factors and Masaoka staging utility in thymic carcinoma require evaluation.

Purpose of the Study:

  • To identify prognostic factors for thymic carcinoma.
  • To assess the effectiveness of Masaoka staging for thymic carcinoma.

Main Methods:

  • Retrospective review of 43 thymic carcinoma surgical cases (1949-1993).
  • Data collected via tumor registry, medical charts, and patient contact.
  • Prognostic factor analysis using Kaplan-Meier and Cox regression for completely resected tumors.

Main Results:

  • Overall 5-year survival was 65%, 10-year survival was 35%.

Related Experiment Videos

  • Overall 5-year recurrence was 65%, 10-year recurrence was 75%.
  • Innominate vessel invasion was the sole significant predictor of survival on univariate and multivariate analyses.

    • Conclusions:

    • Thymic carcinoma exhibits a high recurrence rate.
    • Innominate vessel invasion is a critical negative prognostic indicator.
    • Masaoka staging is inadequate for predicting outcomes in thymic carcinoma.