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Lipoprotein (a) levels in thyroid dysfunction before and after treatment
1Department of Medicine, Dubrava University Hospital, Avenija izvidaca 6, Zagreb, 10000, Croatia.
Croatian Medical Journal
|May 23, 1998
Summary
Thyroid hormones show a moderate impact on lipoprotein (a) [Lp(a)] levels. While hyperthyroidism increased some lipids, neither hyperthyroidism nor hypothyroidism significantly altered Lp(a) concentrations after treatment.
Area of Science:
- Endocrinology
- Lipid Metabolism
- Cardiovascular Risk Factors
Background:
- Lipoprotein (a) [Lp(a)] is an independent risk factor for atherosclerosis.
- Thyroid hormones play a crucial role in regulating lipid metabolism.
- The precise relationship between thyroid status and Lp(a) levels requires further elucidation.
Purpose of the Study:
- To investigate the influence of thyroid hormones on serum lipoprotein (a) [Lp(a)] concentrations.
- To assess changes in Lp(a) and other lipid parameters in patients with hyperthyroidism and hypothyroidism before and after treatment.
Main Methods:
- Studied 11 hyperthyroid, 18 hypothyroid (low Lp(a)), and 13 hypothyroid (high Lp(a)) patients.
- Measured lipids, apoproteins, Lp(a), TSH, and thyroid hormones pre- and post-thyroid normalization.
- Utilized Grave's disease and Hashimoto's disease as models for hyper- and hypothyroidism.
Main Results:
- Hyperthyroidism led to significant increases in total cholesterol, LDL cholesterol, and apo B post-treatment.
- Hypothyroidism resulted in significant decreases in total cholesterol, LDL cholesterol, apo B, and triglycerides post-treatment.
- Neither hyperthyroidism nor hypothyroidism demonstrated statistically significant changes in Lp(a) concentrations after thyroid hormone normalization.
Conclusions:
- Thyroid hormone status exerts only a moderate effect on lipoprotein (a) [Lp(a)] metabolism.
- Lipoprotein (a) [Lp(a)] levels appear relatively stable despite significant alterations in thyroid function.