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Hyponatremia with venlafaxine
G R Masood1, S D Karki, W R Patterson
1Long Term Care Division, Clifton Springs Hospital and Clinic, NY, USA.
The Annals of Pharmacotherapy
|February 26, 1998
Summary
Venlafaxine therapy can cause hyponatremia, a condition of low sodium levels. This case highlights the importance of considering venlafaxine-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH) in patients with hyponatremia.
Area of Science:
- Psychiatry
- Endocrinology
- Pharmacology
Background:
- Selective serotonin-reuptake inhibitors (SSRIs) are commonly prescribed for depression.
- Hyponatremia is a potential adverse effect associated with some antidepressant medications.
Observation:
- A 92-year-old woman developed hyponatremia during venlafaxine treatment for depression.
- Diagnostic workup confirmed Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH).
Findings:
- A temporal link between venlafaxine initiation and hyponatremia onset was established.
- Discontinuation of venlafaxine led to the resolution of hyponatremia.
Implications:
- Venlafaxine, a potent serotonin reuptake inhibitor, may cause hyponatremia similar to SSRIs.
- Clinicians should consider venlafaxine-induced SIADH in the differential diagnosis of hyponatremia.