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Amiodarone-associated granuloma in bone marrow

H Rosenbaum1, Y Ben-Arie, Z S Azzam

  • 1Department of Hematology, Rambam Medical Center, B Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

The Annals of Pharmacotherapy
|February 26, 1998
PubMed
Summary

Amiodarone hydrochloride, an antiarrhythmic drug, may cause bone marrow granulomas. This study observed granulomas in two patients treated with amiodarone, suggesting a potential link.

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Area of Science:

  • Cardiology
  • Hematology
  • Pharmacology

Background:

  • Amiodarone hydrochloride is a Vaughan Williams class III antiarrhythmic agent with potential effects across multiple classes.
  • It is associated with numerous adverse effects, including endocrine, pulmonary, hepatic, and dermatologic complications.

Observation:

  • Bone marrow aspirations and biopsies were conducted on two patients undergoing amiodarone therapy.
  • Both patients presented with asymptomatic bone marrow granulomas.
  • Infections were ruled out as the cause of the granulomas.

Findings:

  • The presence of bone marrow granulomas was observed in two patients treated with amiodarone.
  • A temporal relationship was noted between amiodarone administration and granuloma development.

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Implications:

  • Amiodarone hydrochloride may be implicated in the etiology of bone marrow granulomas.
  • This finding suggests a previously unrecognized adverse effect of amiodarone therapy.
  • Further research is warranted to confirm this association and elucidate the underlying mechanisms.