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Coronary atherosclerosis in subjects with mitral stenosis
Circulation
|September 1, 1976
Summary
Coronary artery atherosclerosis was examined in patients with mitral stenosis. Significantly obstructive atherosclerosis was found in 31.5% of cases, with less widespread distribution compared to clinical coronary disease.
Area of Science:
- Cardiovascular Pathology
- Coronary Artery Disease
- Valvular Heart Disease
Background:
- Mitral stenosis is a significant valvular heart condition.
- The relationship between mitral stenosis and coronary atherosclerosis requires further investigation.
Purpose of the Study:
- To investigate the prevalence and characteristics of coronary atherosclerosis in patients with mitral stenosis.
- To compare the extent of coronary atherosclerosis in mitral stenosis patients with those suffering from clinical coronary disease.
Main Methods:
- Examination of coronary arteries in 60 post-mortem specimens from patients diagnosed with mitral stenosis.
- Identification and quantification of atherosclerotic lesions and other causes of arterial obstruction.
Main Results:
- Nonatherosclerotic obstruction (arterial dysplasia, embolism) was identified in 3 cases.
- Significantly obstructive coronary atherosclerosis was present in 18 of the remaining 57 cases (31.5%).
- Atherosclerosis affected 46% of males and 27% of females; 39% had three or more vessels involved, compared to 79% in a clinical coronary disease cohort.
Conclusions:
- Coronary atherosclerosis is a notable finding in patients with mitral stenosis.
- The distribution of coronary atherosclerotic lesions in mitral stenosis patients is generally less extensive than in patients with diagnosed coronary artery disease.
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