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Updated: Jul 23, 2026

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
Published on: May 19, 2020
[Severe mitral regurgitation with ejection fraction below 40%: pharmacologic therapy is the treatment of choice]
1HerzZentrum Hirslanden, Zürich.
Abstract:
Severe chronic mitral regurgitation with severe left ventricular dysfunction is uncommon. Mitral valve repair is not appropriate and unpredictable in a large proportion of these patients. Mitral valve replacement results in a poor outcome for patients with severe left ventricular dysfunction. Therefore, surgery is not the first therapeutic option for this patient group. Surgery may be considered after optimal medical stabilization and extensive diagnostic evaluation for each individual patient.
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