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Enzyme induction by oral testosterone

S G Johnson, J P Kampmann, E P Bennett

    Clinical Pharmacology and Therapeutics
    |August 1, 1976
    PubMed
    Summary
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    Oral testosterone treatment significantly speeds up drug metabolism in men. This study shows testosterone enhances the liver

    Area of Science:

    • Pharmacology
    • Hepatology
    • Endocrinology

    Background:

    • Testosterone is a crucial hormone with known effects on various bodily functions.
    • Understanding its impact on drug metabolism is important for clinical applications.

    Purpose of the Study:

    • To investigate the effect of oral testosterone administration on the hepatic drug-metabolizing system.
    • To assess changes in drug elimination and liver enzyme activity.

    Main Methods:

    • Six healthy male volunteers received 400 mg of oral testosterone daily for 21 days.
    • Antipyrine half-life was measured to assess drug metabolism.
    • Serum testosterone levels and liver function tests were monitored.

    Main Results:

    Keywords:
    AndrogensBiologyClinical ResearchEndocrine SystemEnzymesEnzymes And Enzyme InhibitorsHepatic EffectsHormonesHuman VolunteersMetabolic EffectsPhysiologyResearch MethodologySteroid Metabolic EffectsTestosterone--administraction and dosageTestosterone--analysisTestosterone--side effects

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    • Intravenous antipyrine half-life significantly decreased from 8.0 +/- 2.7 hr to 5.7 +/- 2.6 hr.
    • Testosterone elimination from serum increased by day 21 compared to day 1.
    • Liver function tests (albumin, bilirubin, prothrombin, ALT, ALP) remained unchanged.

    Conclusions:

    • Oral testosterone treatment induces the hepatic drug-metabolizing system.
    • This induction affects the metabolism of both xenobiotics (antipyrine) and testosterone itself.
    • Testosterone administration can alter drug clearance rates without causing overt liver toxicity.