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Related Experiment Videos

Multifocal electroretinogram in multiple evanescent white dot syndrome

H J Huang1, H Yamazaki, H Kawabata

  • 1Department of Ophthalmology, Kohnodai Hospital, National Center of Neurology and Psychiatry, Chiba, Japan.

Documenta Ophthalmologica. Advances in Ophthalmology
|January 1, 1996
PubMed
Summary

This study investigated electrophysiologic findings in a patient with multiple evanescent white dot syndrome (MEWDS). Results indicate wider retinal dysfunction than previously detected, suggesting optic nerve involvement in MEWDS.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Retinal Imaging

Background:

  • Multiple evanescent white dot syndrome (MEWDS) is an idiopathic inflammatory condition affecting the outer retina.
  • Diagnosis typically relies on fundus examination, visual acuity, and fluorescein angiography.
  • Electrophysiologic testing can provide objective measures of retinal function.

Observation:

  • A 19-year-old female presented with decreased visual acuity and characteristic fundus findings of MEWDS.
  • Fundus examination revealed white dots with hyperfluorescence in the affected eye.
  • Standard electroretinography (ERG) and visual evoked cortical potentials (VEPs) were performed.

Findings:

  • Flicker ERG amplitude was reduced, while single-flash ERG was normal.

Related Experiment Videos

  • Pattern VEP P100 latency showed slight prolongation.
  • Multifocal ERG (mfERG) amplitudes were significantly reduced in scotoma areas and moderately reduced elsewhere in the central field.

    • Implications:

    • Electrophysiologic findings suggest retinal dysfunction in MEWDS may be more extensive than clinically apparent.
    • Prolonged VEP latency indicates potential optic nerve involvement in the disease process.
    • mfERG is a valuable tool for assessing the full extent of retinal dysfunction in MEWDS.