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Differential signaling through the T cell receptor: from biochemistry to transplantation tolerance

J Madrenas1, A I Lazarovits

  • 1John P. Robarts Research Institute, University of Western Ontario, London, Canada.

Histology and Histopathology
|February 26, 1998
PubMed

Recent advances in our understanding of the structural nature of T cell activation and signal transduction from the T cell receptor for antigen make possible the development of new tolerogenic strategies. Here, we summarize the evidence supporting a critical role for the co-receptor molecule (CD4 or CD8) and CD45 in determining the pattern of T cell receptor-mediated signaling. The consequences of this differential signaling can range from T cell proliferation and cytokine production to the establishment of a state of proliferative unresponsiveness known as T cell anergy. Inducing T cell anergy can be an alternative approach for the establishment of transplantation tolerance.

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