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Related Experiment Videos

CD8+ T-cell clones in old mice

C C Ku1, B Kotzin, J Kappler

  • 1Howard Hughes Medical Institute, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.

Immunological Reviews
|February 26, 1998
PubMed
Summary

Large clones of CD8+ T cells expand in old mice and humans, potentially due to continuous antigen exposure. Their frequency is influenced by genetics and infection, suggesting an immune response to persistent antigens.

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Area of Science:

  • Immunology
  • T cell biology
  • Aging research

Background:

  • Old mice and humans harbor large clones of CD8+ alpha beta T cell receptor (TCR)+ T cells.
  • The presence of V beta 7+ clones is elevated in mouse hepatitis virus-infected mice compared to uninfected controls.
  • The expansion of these T cell clones is influenced by non-MHC genes and animal origin.

Purpose of the Study:

  • To investigate the characteristics and potential drivers of CD8+ alpha beta TCR+ T cell clonal expansion in aging.
  • To understand the in vivo behavior and antigen specificity of these expanded T cell populations.

Main Methods:

  • Analysis of T cell populations in aged mice and humans.
  • In vivo cell transfer experiments.
  • Assessment of T cell proliferation and turnover kinetics.

Main Results:

  • CD8+ alpha beta TCR+ T cell clones are prevalent in aged individuals.
  • Clones exhibit anergy to acute in vitro stimuli but proliferate in vivo.
  • Clonal expansion occurs slowly but continuously after adoptive transfer.
  • Non-MHC genes and host origin affect clone frequency.

Conclusions:

  • CD8+ alpha beta TCR+ T cell clones likely arise from continuous exposure to specific exogenous or autoantigens.
  • These clones maintain proliferative capacity in vivo despite in vitro anergy.
  • Understanding these clones is crucial for comprehending age-related immune changes.

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