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Related Experiment Videos

Dextro-naloxone counteracts amphetamine-induced hyperactivity

N Chatterjie1, J A Sechzer, K W Lieberman

  • 1New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA.

Pharmacology, Biochemistry, and Behavior
|February 26, 1998
PubMed
Summary
This summary is machine-generated.

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The opiate receptor antagonist l-naloxone blocks d-amphetamine

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • d-amphetamine is a stimulant that increases locomotor activity.
  • l-naloxone is an opiate receptor antagonist that can counteract some stimulant effects.

Purpose of the Study:

  • To investigate the mechanism by which l-naloxone counteracts d-amphetamine-induced hyperactivity.

Main Methods:

  • Mice were administered d-amphetamine alone or in combination with l-naloxone or d-naloxone.
  • Locomotor activity was measured to assess the effects of the treatments.

Main Results:

  • l-naloxone significantly reduced d-amphetamine-induced hyperactivity.
  • d-naloxone, which lacks opiate antagonist activity, also blocked the hyperactivity.
  • This suggests a non-opiate receptor mechanism is involved.

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Conclusions:

  • The results indicate that a non-opiate receptor pathway mediates the counteraction of amphetamine's stimulant effects by naloxone enantiomers.
  • This finding suggests a novel mechanism for modulating stimulant and euphoriant drug actions.