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Related Experiment Videos

Time-dependent differences in the rat's motor response to amphetamine

O Gaytan1, A Swann, N Dafny

  • 1Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, 77225, USA.

Pharmacology, Biochemistry, and Behavior
|February 26, 1998
PubMed
Summary

d-amphetamine significantly increased locomotor activity in rats at both light and dark cycle phases. The 1.25 mg/kg dose maximally enhanced activity, with effects duration increasing with higher d-amphetamine doses.

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Adolescent rat circadian activity is modulated by psychostimulants.

Brain research·2011

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • The effects of psychostimulants like d-amphetamine are influenced by the time of administration within the circadian cycle.
  • Understanding these chronopharmacological effects is crucial for both therapeutic applications and understanding drug action.

Purpose of the Study:

  • To investigate the dose-dependent motor effects of d-amphetamine administered at the beginning of the light and dark phases in rats.
  • To analyze how different motor behavior indices respond to d-amphetamine across different times of day.

Main Methods:

  • Rats were administered varying doses of d-amphetamine (0.6-10 mg/kg) or vehicle at 1 hour into the light or dark phase.
  • A computerized system monitored five distinct motor behavior indices over time.

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  • Locomotor activity and stereotypic behaviors were quantified and compared to baseline and control groups.

    • Main Results:

    • All tested doses of d-amphetamine significantly increased locomotor activity compared to baseline, regardless of administration time.
    • The 1.25 mg/kg dose of d-amphetamine produced the maximum increase in locomotor activity.
    • Higher doses of d-amphetamine led to longer-lasting effects, and stereotypic behaviors differed between light and dark phase administration.

    Conclusions:

    • D-amphetamine robustly enhances locomotor activity in rats, with peak effects at 1.25 mg/kg.
    • While the overall locomotor response to d-amphetamine is consistent, specific stereotypic effects vary with the circadian phase.
    • These findings highlight the importance of circadian timing in psychostimulant drug effects.