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Cerebral glucose metabolism and centrotemporal spikes
P Van Bogaert1, D Wikler, P Damhaut
1Department of Neurology (Pediatric Neurology), ULB-Hôpital Erasme, Brussels, Belgium.
Epilepsy Research
|February 26, 1998
Summary
Positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) did not reveal significant metabolic changes in children with benign childhood epilepsy with centrotemporal spikes (BCECS). This suggests FDG-PET may help distinguish idiopathic from symptomatic childhood epilepsy.
Area of Science:
- Neuroscience
- Pediatric Neurology
- Medical Imaging
Background:
- Regional glucose hypometabolism is linked to refractory epilepsy, but its association with interictal spiking is debated.
- Animal models suggest interictal spikes increase glucose metabolism, contradicting findings in some human epilepsy types.
Purpose of the Study:
- To investigate the relationship between interictal spiking and regional cerebral glucose metabolism in children with focal spikes.
- To determine if 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) can detect metabolic changes associated with interictal spikes in idiopathic epilepsy.
Main Methods:
- Studied 13 children (11 with benign childhood epilepsy with centrotemporal spikes (BCECS), 2 controls) using FDG-PET.
- Analyzed regional cerebral glucose metabolism for asymmetries using statistical parametric mapping (SPM).
- Compared metabolic patterns between left-sided and right-sided centrotemporal spikes.
Main Results:
- No statistically significant differences in regional glucose metabolism were found between groups with left-sided and right-sided centrotemporal spikes.
- FDG-PET did not demonstrate metabolic alterations linked to interictal spiking in BCECS patients.
Conclusions:
- FDG-PET may not detect metabolic changes associated with interictal spiking in BCECS.
- FDG-PET could be a valuable tool for differentiating between idiopathic and symptomatic partial epilepsy in children.