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Related Experiment Videos

Cerebral trypanosomiasis in native cattle

D Tuntasuvan1, N Sarataphan, H Nishikawa

  • 1National Institute of Animal Health, Kasetklang, Bangkok, Thailand.

Veterinary Parasitology
|February 27, 1998
PubMed
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Outbreaks of cattle trypanosomiasis, caused by Trypanosoma evansi, occurred in Thailand. The parasite was detected in blood and nervous tissues of affected cattle, confirming its role in the disease.

Area of Science:

  • Veterinary Parasitology
  • Neurology
  • Infectious Diseases

Background:

  • Trypanosomiasis is a significant disease affecting livestock globally.
  • Nervous system involvement in bovine trypanosomiasis can lead to severe clinical signs and mortality.
  • Outbreaks of suspected trypanosomiasis in cattle were reported in Petchaboon province, Thailand.

Purpose of the Study:

  • To investigate outbreaks of suspected trypanosomiasis in native cattle (Bos indicus) in Thailand.
  • To identify the causative agent, Trypanosoma evansi, and confirm its presence in affected animals.
  • To determine the extent of parasite detection in blood and central nervous system tissues.

Main Methods:

  • Clinical examination of cattle exhibiting nervous symptoms.

Related Experiment Videos

  • Collection and examination of blood samples using mouse inoculation and indirect fluorescent antibody test (IFAT).
  • Microscopic examination of organ impression smears and cerebrospinal fluid (CSF).
  • Isolation of trypanosomes from brain and spinal cord tissues via mouse inoculation.

    • Main Results:

    • Forty-two cattle presented with neurological signs including circling, aggression, convulsions, and death.
    • Trypanosoma evansi was confirmed in blood samples from cattle on two affected farms.
    • Detection rates varied between farms, with Farm A showing 100% positivity by mouse inoculation and IFAT.
    • T. evansi was identified in impression smears of organs and CSF from deceased cattle.
    • Trypanosomes were successfully isolated from various parts of the central nervous system.

    Conclusions:

    • Trypanosoma evansi was confirmed as the causative agent of the observed nervous disease in cattle in Petchaboon province.
    • The parasite demonstrated neurotropism, infecting and being detectable within the brain and spinal cord.
    • These findings highlight the potential for severe neurological disease and mortality in cattle due to T. evansi infection.