[Inhibitors of calcium-calmodulin system and hypothalamic sex differentiation in rats. Biochemical parameters]

The systemic action of certain psychotropic drugs (haloperidol, penfluridol, trifluoperazine pimozide and verapamil) inhibitors of calcium-calmodulin-system, some biochemical and morphological parameters during the sexual differentiation of hypothalamus in neonatal (72 hours) male and androgenized female rats were studied. The hypothalamic weight in normal adult rats of both sexes not changed (39.7 +/- 3.79 vs 40.57 +/- 7.60 mg); however, verapamil increased the hypothalamic weight (table II), haloperidol and pimozide were the most effective (1.50 +/- 0.49 g and 2.00 +/- 0.11 g respectively). The testosterone administered to newborn females decreased the ovary development (46.3 +/- 4.5 mg. vs 23.1 +/- 2.7 mg), the haloperidol and pimozide partially reverted this effect.