Related Experiment Videos
Toxicity considerations when revising the Nordic nutrition recommendations
1Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Copenhagen, Denmark.
The Journal of Nutrition
|March 21, 1998
Summary
Nordic countries established upper intake limits for iron, zinc, iodine, and selenium. Safety margins were small, highlighting the need to consider trace element interactions and long-term exposure effects.
Area of Science:
- Nutritional Toxicology
- Public Health Nutrition
Background:
- Nordic countries have collaborated on nutrition recommendations since 1980.
- The 3rd revision necessitated a toxicological assessment of specific trace elements.
Purpose of the Study:
- To evaluate the toxicology of selected trace elements for setting safe upper intake levels.
- To inform the joint nutrition recommendations for Nordic countries.
Main Methods:
- A joint working group of nutritionists and toxicologists convened.
- Toxicological data was reviewed to establish upper intake limits for key trace elements.
Main Results:
- Upper intake limits were determined for iron, zinc, iodine, and selenium.
- Small safety factors were noted between reported adverse effect levels and suggested upper limits.
Conclusions:
- The toxicological evaluation for essential trace elements requires consideration of inter-element interactions.
- Long-term exposure to moderately elevated trace element intakes is a critical factor in safety assessments.