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Related Experiment Videos

A perspective on mineral standards

W Mertz1

  • 1Human Nutrition Research Center, ARS, USDA, Beltsville, MD 20705, USA.

The Journal of Nutrition
|March 21, 1998
PubMed
Summary
This summary is machine-generated.

Establishing safe nutrient intake ranges is crucial for human survival. Recent findings narrow these ranges, highlighting the need for updated guidelines for essential trace elements.

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Area of Science:

  • Nutritional Science
  • Toxicology
  • Human Health

Background:

  • Adequate nutrient intake is vital for human survival.
  • Historically, safe and adequate intake ranges for nutrients were determined independently by nutritionists and toxicologists.
  • Recent refinements in adequacy and safety criteria have narrowed these intake ranges, sometimes eliminating the safe zone.

Purpose of the Study:

  • To discuss common principles for establishing safe and adequate intake ranges for essential trace elements.
  • To explore perspectives on implementing these principles.

Main Methods:

  • Review of historical nutritional and toxicological data.
  • Analysis of findings from the 1992 Herndon Conference.
  • Discussion of principles for defining nutrient deficiency and toxicity endpoints.

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Main Results:

  • Safe and adequate intake ranges for nutrients are not single values but a spectrum.
  • Refined criteria have led to higher requirement estimates and lower toxicity thresholds.
  • The range of safe and adequate intakes has narrowed for some nutrients.

Conclusions:

  • Common principles can aid in defining safe and adequate intake ranges for essential trace elements.
  • Implementing these principles requires considering both deficiency and toxicity levels.
  • Updated guidelines are necessary due to evolving understanding of nutrient requirements and safety limits.