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[Preoperative irradiation in hypernephroid carcinoma]

A Rost, W Brosig, H Ernst

Helvetica Chirurgica Acta

|July 1, 1976

Summary

Preoperative radiation therapy for hypernephroma (kidney cancer) before surgery demonstrated positive survival rates. This approach aimed to reduce tumor size and prevent cancer spread, with acceptable surgical risks.

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[Epi-Bowman Keratectomy: Clinical Evaluation of a New Method of Surface Ablation].

Klinische Monatsblatter fur Augenheilkunde·2017

Area of Science:

Oncology
Radiation Oncology
Surgical Oncology

Context:

Hypernephroma (renal cell carcinoma) treatment historically involved radical nephrectomy.
The RICHES protocol proposed preoperative radiation therapy to improve outcomes.
Evaluating the efficacy and safety of this combined treatment approach.

Purpose:

To assess the impact of preoperative radiation therapy on survival rates in hypernephroma patients.
To determine the effectiveness of radiation in devitalizing tumor cells and preventing metastasis.
To evaluate the role of preoperative radiation in facilitating radical nephrectomy and its effect on surgical outcomes.

Summary:

A study of 100 hypernephroma patients (1967-1975) treated with preoperative radiation (3000 rads) followed by radical nephrectomy.
Survival rates at 1, 3, and 5 years post-treatment were 80%, 63%, and 46% respectively.
Tumor size reduction was observed in one-third of cases, with a 2% surgical mortality rate. The 6-week delay showed no adverse effect.

Impact:

Preoperative radiation therapy is a viable strategy for hypernephroma, potentially improving survival and surgical feasibility.
The findings support the use of neoadjuvant radiation to enhance oncological outcomes in kidney cancer.
This study provides long-term data on a combined modality treatment for advanced renal cell carcinoma.

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