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An area specialized for spatial working memory in human frontal cortex

S M Courtney1, L Petit, J M Maisog

  • 1Laboratory of Brain and Cognition, National Institute of Mental Health, Building 10, Room 4C104, 10 Center Drive, Bethesda, MD 20892-1366, USA. Susan_Courtney@nih.gov

Science (New York, N.Y.)
|March 21, 1998
PubMed
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Researchers identified a brain region specialized for spatial working memory in humans using fMRI. This area, located in the superior frontal sulcus, differs from the monkey brain region, potentially explaining past disputes about its existence.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Working memory is crucial for active information maintenance and use.
  • In monkeys, the principal sulcus is key for spatial working memory.
  • The human homolog for spatial working memory remains debated.

Purpose of the Study:

  • To identify and localize the human brain region specialized for spatial working memory.
  • To resolve the dispute regarding the existence and location of human spatial working memory areas.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was employed in human participants.
  • Task-based neuroimaging was used to observe brain activity during spatial working memory tasks.

Main Results:

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  • A distinct area in the superior frontal sulcus showed specialization for spatial working memory.
  • This identified region is situated more superiorly and posteriorly compared to the monkey homolog.

Conclusions:

  • The superior frontal sulcus hosts a human brain region critical for spatial working memory.
  • Positional differences between human and monkey brains may account for previous identification challenges.