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Endogenous cryptococcal endophthalmitis

S J Sheu1, Y C Chen, N W Kuo

  • 1Department of Ophthalmology, Veterans General Hospital, Kaohsiung, Taiwan.

Ophthalmology
|February 28, 1998
PubMed
Summary
This summary is machine-generated.

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This case study highlights a rare instance of cryptococcal endophthalmitis in an immunocompromised patient without meningitis. Prompt diagnosis via retinal biopsy and combined antifungal therapy led to successful treatment of this ocular fungal infection.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Mycology

Background:

  • Cryptococcal endophthalmitis is a rare ocular infection, often linked to disseminated cryptococcosis.
  • This report details a unique case of endogenous fungal endophthalmitis without prior meningeal involvement.

Observation:

  • A 45-year-old female with systemic lupus erythematosus on immunosuppressants presented with unilateral vision loss.
  • Ophthalmic examination revealed significant exudative retinal detachment and vitreous infiltration.

Findings:

  • Retinal biopsy confirmed cryptococcal endophthalmitis.
  • Histopathology of vitreous and epiretinal membrane samples indicated disease recurrence.
  • Combined systemic and intravitreal antifungal treatment (amphotericin B, fluconazole) eradicated the infection.

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Implications:

  • Retinal biopsy is crucial for diagnosing cryptococcal endophthalmitis, especially in atypical presentations.
  • A multimodal antifungal approach, including intravitreal injections, is effective for managing ocular cryptococcosis.
  • This case underscores the importance of considering fungal endophthalmitis in immunocompromised patients with unexplained visual decline.