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Updated: Sep 16, 2026

Murine Model of CD40-activation of B cells
Published on: March 5, 2010
[Activation of blood lymphocytes in lung cancer patients with polyclonal mitogens]
E K Oleĭnik1, I E Bakhlaev, A I Ageenko
1Institute of Biology, Karelian Research Center of Russian Academy of Sciences, Petrozavodsk.
Abstract:
The lymphocyte proliferative response to PHA, Con A and PWM was studied in patients with lung tumors (stage I-IV) and other histological types. Disorders in the mitogen-induced lymphocyte activation were identified in more advanced tumors. Certain peculiarities of lymphocyte proliferative activity were found to be determined by histological pattern and localization. A method of evaluation of blasttransformation consequences with due account of lymphocyte functional activity in cancer patients is suggested.
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