Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clonality in hematopoietic disorders

T Hotta1

  • 1Fourth Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.

International Journal of Hematology
|February 28, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Monitoring the build-up of hydrogen polarization for polarized hydrogen-deuteride (HD) targets with nuclear magnetic resonance (NMR) at 17 T.

The Review of scientific instruments·2020
Same author

Search for η^{'} Bound Nuclei in the ^{12}C(γ,p) Reaction with Simultaneous Detection of Decay Products.

Physical review letters·2020
Same author

Differential Cross Section and Photon-Beam Asymmetry for the γ[over →]p → π^{-}Δ^{++}(1232) Reaction at Forward π^{-} Angles for E_{γ}=1.5-2.95  GeV.

Physical review letters·2018
Same author

Horizontal rectal transection using an endolinear stapler for laparoscopic low anterior resection.

Techniques in coloproctology·2017
Same author

Interference Effect between ϕ and Λ(1520) Production Channels in the γp→K^{+}K^{-}p Reaction near Threshold.

Physical review letters·2016
Same author

Randomized clinical trial of defaecatory function after anterior resection for rectal cancer with high versus low ligation of the inferior mesenteric artery.

The British journal of surgery·2015
Same journal

Modified short-course fludarabine-based conditioning regimen for salvage cord blood transplantation after graft failure.

International journal of hematology·2026
Same journal

Cytarabine-based induction and oral maintenance therapy for a single system with single-site Langerhans cell histiocytosis.

International journal of hematology·2026
Same journal

Long-term treatment-free remission in CML after early dasatinib discontinuation due to interstitial pneumonitis.

International journal of hematology·2026
Same journal

Correction to: Low reticulocyte count at infusion is a risk factor for high-grade cytokine release syndrome in chimeric antigen receptor T cell therapy.

International journal of hematology·2026
Same journal

The efficacy of prophylactic tranexamic acid in patients with hematologic malignancy: a systematic review and meta-analysis.

International journal of hematology·2026
Same journal

Current status and challenges of TCR-T cell therapy for AML/MDS.

International journal of hematology·2026
See all related articles

X-inactivation analysis reveals that while monoclonal hematopoiesis is common in blood cancers, it

Area of Science:

  • Hematology
  • Genetics
  • Oncology

Background:

  • X-inactivation analysis of polymorphic X-linked genes (e.g., PGK, HPRT, HU-MARA, DXS255) is a standard method for assessing hematologic diseases.
  • Previous research indicated high monoclonality in aplastic anemia and clonal remission in leukemia.
  • Recent findings challenge these earlier conclusions, suggesting lower incidences of clonal hematopoiesis in aplastic anemia and leukemia remission when accounting for skewed X-inactivation and using internal controls.

Purpose of the Study:

  • To re-evaluate the incidence of clonal hematopoiesis in hematologic diseases, particularly aplastic anemia and leukemia remission.
  • To investigate the presence of polyclonal hematopoietic progenitor cells in patients with monoclonal peripheral blood granulocytes.
  • To explore potential novel therapeutic strategies based on these findings.

Related Experiment Videos

Main Methods:

  • Utilizing X-inactivation analysis of polymorphic X-linked genes.
  • Comparing X-inactivation patterns in different cell populations (e.g., peripheral blood granulocytes vs. T-lymphocytes).
  • Analyzing bone marrow samples to detect residual polyclonal hematopoietic progenitor cells.

Main Results:

  • Monoclonal hematopoiesis is confirmed in myelodysplastic syndromes (MDS), myeloproliferative disorders (MPD), and leukemia.
  • The incidence of true clonal hematopoiesis in aplastic anemia and leukemia remission is lower than previously reported, especially after ruling out skewed X-inactivation.
  • Polyclonal hematopoietic progenitor cells can coexist with monoclonal granulocytes in MDS and MPD patients.

Conclusions:

  • Earlier assessments of monoclonality in aplastic anemia and leukemia remission may have overestimated incidence due to methodological limitations.
  • The detection of residual polyclonal progenitor cells in MDS/MPD patients suggests a complex cellular landscape.
  • These findings may pave the way for new treatment approaches targeting distinct cell populations in hematologic malignancies.