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Related Experiment Videos

Ependymomas and ependymoblastomas in children

G J Dohrmann, J R Farwell, J T Flannery

    Journal of Neurosurgery
    |September 1, 1976
    PubMed
    Summary

    This study analyzed childhood ependymomas and ependymoblastomas in Connecticut, finding increased incidence and better survival for ependymomas with surgery and irradiation. Treatment significantly impacted survival rates for these central nervous system tumors.

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    Area of Science:

    • Pediatric Oncology
    • Neuropathology
    • Epidemiology

    Background:

    • Ependymomas and ependymoblastomas are primary central nervous system tumors in children.
    • Historical data on the incidence, characteristics, and outcomes of these tumors are crucial for understanding disease progression and treatment efficacy.

    Purpose of the Study:

    • To analyze the incidence, clinical features, and survival rates of ependymoma and ependymoblastoma in children.
    • To compare the outcomes of different treatment modalities and tumor locations.
    • To investigate trends in diagnosis and operative mortality over time.

    Main Methods:

    • Retrospective analysis of histologically verified cases of ependymoma and ependymoblastoma in children diagnosed between 1935 and 1973 in Connecticut.
    • Review of tumor origin (intracranial vs. intraspinal), age at diagnosis, sex distribution, tumor location (supratentorial vs. infratentorial), presenting symptoms, and seizure rates.
    • Comparison of survival rates based on tumor type, location, and treatment received (operation and irradiation vs. other methods).
    • Analysis of operative mortality and the potential impact of steroid therapy.

    Main Results:

    • Ependymal tumors accounted for 9% of intracranial and 24% of intraspinal neoplasms. Incidence increased since the mid-1950s.
    • Supratentorial ependymoblastomas had higher seizure rates (38%) compared to supratentorial ependymomas (9%).
    • Supratentorial ependymal neoplasms showed significantly longer survival than infratentorial ones. Children with supratentorial ependymomas survived longer than those with ependymoblastomas.
    • Treatment with operation and irradiation significantly improved survival compared to other methods, with better outcomes for ependymomas over ependymoblastomas.
    • Operative mortality decreased significantly over the study period, potentially due to steroid therapy, though steroids did not significantly affect survival length.

    Conclusions:

    • Childhood supratentorial ependymomas have a better prognosis than ependymoblastomas, contrary to previous reports.
    • Combined surgical and irradiation therapy offers significantly improved survival for ependymal tumors.
    • Decreased operative mortality suggests advancements in surgical care during the study period.

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