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Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
Published on: June 23, 2012
Isolation of genomic fragments from polymorphic regions by representational difference analysis
1Laboratory of Developmental Genetics, Wadsworth Center, David Axelrod Institute for Public Health, Albany, New York 12201-2002, USA.
Methods (San Diego, Calif.)
|March 21, 1998
Abstract:
Representational difference analysis is an effective technique for isolating the differences between two nearly identical genomes. We have found the technique to be extremely valuable in our analyses of mouse germline mutations. We also present several technical improvements in the procedure that make it more efficient and reliable.

