Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure and function of the hemolymph node in rats

K Sakita1, M Fujino, T Koshikawa

  • 1First Department of Pathology, Nagoya University School of Medicine, Japan.

Nagoya Journal of Medical Science
|March 3, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic and transcriptomic analyses of melanoma in Japanese patients reveal candidate biomarkers for immune checkpoint inhibitor responders.

Communications medicine·2026
Same author

Gastrointestinal: Relapsed Type 1 autoimmune pancreatitis mimicking pancreatic cancer.

Journal of gastroenterology and hepatology·2024
Same author

Gastrointestinal: Successful endoscopic treatment of multiple large common bile duct stones with benign biliary stricture in a case of distal gastrectomy with Billroth II reconstruction.

Journal of gastroenterology and hepatology·2022
Same author

Safety and efficacy of PD-1/PD-L1 blockade in patients with preexisting antinuclear antibodies.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2019
Same author

Beam Energy and Centrality Dependence of Direct-Photon Emission from Ultrarelativistic Heavy-Ion Collisions.

Physical review letters·2019
Same author

Necrotizing Sweet syndrome in a patient with myelodysplastic syndrome.

Clinical and experimental dermatology·2017
Same journal

A challenging case of giant atypical fibroxanthoma on non-chronically sun-damaged skin: a case report with TP53 somatic mutation (c.375+1 G>A).

Nagoya journal of medical science·2026
Same journal

A case of reconstruction for triple-negative metaplastic breast cancer that enlarged rapidly during neoadjuvant immunochemotherapy.

Nagoya journal of medical science·2026
Same journal

Knacks and pitfalls of retroperitoneal sarcoma surgery, part 3: resection of tumors involving large retroperitoneal vessels.

Nagoya journal of medical science·2026
Same journal

Objective food store access was associated with calcium intake among older Japanese adults: a cross-sectional analysis from the Japan Gerontological Evaluation Study at Taisetsu Community Hokkaido.

Nagoya journal of medical science·2026
Same journal

Knacks and pitfalls of retroperitoneal sarcoma surgery, part 1: preparation for tumor resection.

Nagoya journal of medical science·2026
Same journal

A case of follicular dendritic cell sarcoma with the expression of SRY-box transcription factor 9.

Nagoya journal of medical science·2026
See all related articles

Hemolymph nodes (HLs) possess unique structures allowing erythrocyte passage, suggesting functionally open blood vessels. Their immunologic function falls between ordinary lymph nodes and the spleen.

Area of Science:

  • Immunology
  • Lymphatic System Biology
  • Comparative Anatomy

Background:

  • Hemolymph nodes (HLs) are distinct lymphoid organs characterized by erythrocytes within their lymphatic sinuses.
  • Understanding the structural and functional differences between HLs, ordinary lymph nodes (OLs), and the spleen is crucial for elucidating immune system organization.

Purpose of the Study:

  • To compare the internal structure and immunologic function of HLs with OLs and the spleen.
  • To investigate the vascular permeability and immune cell responses within HLs.

Main Methods:

  • Electron microscopy to examine ultrastructure and erythrocyte passage.
  • Intravenous injection of carbon particles and lipopolysaccharide (LPS) to assess particle deposition and immune cell migration.
  • Immunohistochemistry to identify IgM-stained lymphocytes.

Related Experiment Videos

  • Plaque-forming cell assays using sheep red blood cells (SRBC) to evaluate antibody production.

    • Main Results:

    • Electron microscopy showed erythrocytes traversing blood vessel walls in the intermediate sinus area (IMSA) of HLs, but no direct lymph-blood vessel communication.
    • HLs exhibited significant carbon particle deposition in the IMSA post-injection, unlike OLs.
    • LPS reached the IMSA of HLs and induced increased IgM-stained lymphocytes compared to OLs.
    • HLs demonstrated an antibody-producing capacity intermediate between OLs and the spleen.

    Conclusions:

    • HLs possess functionally open blood vessels in the IMSA, facilitating immune cell interactions.
    • HLs represent a unique lymphoid organ with structural and functional characteristics bridging those of OLs and the spleen.