Human adult-onset lactase decline: an update

Area of Science:

• Gastroenterology
• Human Biology
• Nutritional Science

Background:

• Human adult-onset lactase decline is a common biologic feature of intestinal maturation worldwide.
• Lactose digestion and absorption are influenced by lactase levels, gastric emptying, and colonic salvage.
• Lactose intolerance symptoms can be managed with commercial lactase products, but understanding variability is key for better interventions.

Purpose of the Study:

• To explore the variability in lactose tolerance and its implications.
• To identify potential interventions for improving lactose utilization.
• To assess the link between adult-onset lactase decline and health risks like osteoporosis and calcium malabsorption.

Main Methods:

• The study reviews existing literature on human adult-onset lactase decline.
• It analyzes factors influencing lactose digestion and absorption variability.
• It examines the association between lactase decline and conditions such as osteoporosis and impaired calcium absorption.

Main Results:

• Adult-onset lactase decline is a widespread phenomenon affecting lactose digestion.
• Variability in lactose tolerance is due to lactase levels, gastric emptying, and colonic salvage.
• Lactase decline may increase osteoporosis risk and impair calcium absorption, especially in the elderly with co-existing conditions.

Conclusions:

• Further research into lactose digestion variability can lead to improved interventions for lactose intolerance.
• Adult-onset lactase decline is a potential risk factor for osteoporosis and calcium malabsorption.
• Elderly individuals with lactase decline should carefully monitor their calcium nutrition status.