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Endoscopic injection therapy for bleeding peptic ulcer using absolute alcohol

S P Misra¹, M Dwivedi

¹Department of Gastroenterology, MLN Medical College, Allahabad, India.

Tropical Doctor

|March 3, 1998

Summary

Absolute alcohol injection effectively stopped bleeding in all 76 patients with peptic ulcers. This safe and effective endoscopic therapy, particularly for gastric ulcers, shows promising results in Indian patients.

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Area of Science:

Gastroenterology
Endoscopic Therapy

Background:

Peptic ulcer bleeding is a common gastrointestinal emergency.
Injection therapy with sclerosants and adrenaline is a recognized hemostatic method.
Limited data exists on injection therapy for bleeding peptic ulcers in India.

Purpose of the Study:

To evaluate the efficacy and safety of absolute alcohol injection therapy for bleeding peptic ulcers in an Indian population.
To compare outcomes between gastric and duodenal ulcers treated with injection therapy.

Main Methods:

A prospective study involving 76 patients with bleeding peptic ulcers.
Injection therapy using absolute alcohol was administered endoscopically.
Patients were monitored for hemostasis, recurrence, and complications.

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Main Results:

Successful hemostasis was achieved in all 76 patients (100%).
Bleeding recurrence occurred in two patients, managed with a second injection.
Gastric ulcer patients required significantly more blood transfusions (76%) than duodenal ulcer patients (22%) (P < 0.001).
No complications related to the injection therapy were observed.

Conclusions:

Injection therapy with absolute alcohol is a safe and highly effective treatment for bleeding peptic ulcers.
The procedure demonstrates significant success in the Indian patient cohort.
Absolute alcohol injection presents a viable endoscopic option for managing peptic ulcer hemorrhage.