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Benefit of dynamic over static incubation in the detection of a low-level HBsAg (chronic carrier) bone donor
Vox Sanguinis
|March 3, 1998
Abstract
Background:
Hepatitis B infection can be transmitted by organ or tissue transplantation.
Case Report:
A 40-year-old man received a bone graft from a donor who tested negative for HbsAg with a static-mode assay. The same donor, on a subsequent donation, was found to be HbsAg-positive with a dynamic mode assay. The archival sample from the initial donation also tested HbsAg-positive with the dynamic-mode assay. The recipient of the bone, who had received HBV vaccine in the past, did not develop clinical or laboratory evidence of HBV infection.
Conclusions:
This case highlights the importance of sensitive microbiological test protocols in the context of tissue banking.