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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Treatment of diastolic dysfunction in hypertensive patients without left ventricular hypertrophy

E Molinero1, N Murga, J D Sagastagoitia

  • 1Cardiology Service, Basurto Hospital, Bilbao, Spain.

Journal of Human Hypertension
|March 3, 1998
PubMed

Insights

Verapamil SR 240 mg improved diastolic dysfunction in hypertensive patients, unlike amiloride + hydrochlorothiazide. Verapamil also reduced heart wall thickness, suggesting potential benefits beyond blood pressure control for diastolic heart function.

Area of Science:

  • Cardiology
  • Pharmacology
  • Hypertension Research

Background:

  • Diastolic dysfunction is common in hypertensive patients.
  • Left ventricular hypertrophy (LVH) is a known complication, but diastolic dysfunction can occur without it.
  • Effective treatment for diastolic dysfunction in non-LVH hypertensive patients is crucial.

Purpose of the Study:

  • To compare the effects of verapamil SR 240 mg (V) and amiloride 5 mg + hydrochlorothiazide 50 mg (AH) on diastolic dysfunction.
  • To assess changes in cardiac structure and function in hypertensive patients without LVH.

Main Methods:

  • A 6-month randomized trial involving 26 hypertensive patients with diastolic dysfunction and no LVH.
  • Doppler-echocardiography was used to assess diastolic function and cardiac parameters at baseline and follow-up visits.
  • Patients underwent a 2-week washout period before treatment allocation.

Main Results:

  • Both verapamil SR and amiloride + hydrochlorothiazide effectively controlled blood pressure.
  • Verapamil SR demonstrated significant improvements in diastolic function, including reduced peak A wave, increased E/A ratio, and shortened deceleration time.
  • Verapamil SR also led to a significant reduction in wall thickness compared to amiloride + hydrochlorothiazide after 24 weeks.

Conclusions:

  • Verapamil SR 240 mg shows promise in improving diastolic function in hypertensive patients without LVH.
  • The combination of amiloride + hydrochlorothiazide controlled blood pressure but did not improve diastolic function.
  • Larger studies are warranted to confirm these findings and explore the long-term effects of verapamil SR.

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