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Sex differences in brain aging: a quantitative magnetic resonance imaging study

C E Coffey1, J F Lucke, J A Saxton

  • 1Department of Psychiatry, Henry Ford Health System, Detroit, Mich 48202, USA. ecoffey1@hfhs.org

Archives of Neurology
|March 3, 1998
PubMed
Summary

Brain aging shows sex differences, with men exhibiting greater changes in certain brain structures than women. Further research is needed to understand the neurobiological basis of these sex-specific aging patterns.

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Area of Science:

  • Neuroimaging
  • Gerontology
  • Neuroscience

Background:

  • Limited understanding of sex-based variations in age-related brain structure changes.
  • Investigating sex differences in brain aging is crucial for understanding cognitive decline.

Purpose of the Study:

  • To investigate the impact of sex on age-related structural brain changes.
  • To identify specific brain regions where aging effects differ between men and women.

Main Methods:

  • Quantitative magnetic resonance imaging (MRI) of the brain in 330 elderly volunteers (66-96 years).
  • Computer-assisted measurement of global and regional brain size from T1-weighted images.
  • High measurement reliability was ensured through blinded assessments.

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Main Results:

  • Men showed significantly greater age-related increases in peripheral cerebrospinal fluid volume and parieto-occipital region area compared to women.
  • Age affected other brain regions (e.g., cerebral hemisphere volume, ventricles) similarly in both sexes.
  • Brain structure asymmetries were not influenced by aging in either sex.

Conclusions:

  • Aging effects on certain brain structures appear more pronounced in men than women.
  • Findings align with existing literature on sex differences in brain aging.
  • Further investigation into the neurobiological and functional aspects of these sex differences is warranted.