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Cochlear electrically evoked emissions modulated by mechanical transduction channels

G K Yates1, D L Kirk

  • 1The Auditory Laboratory, Department of Physiology, The University of Western Australia, Nedlands 6907, Western Australia, Australia.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|April 18, 1998
PubMed
Summary

Electrically evoked oto-acoustic emissions suggest extrinsic electrical currents enter cochlear hair cells mainly through transduction channels, not capacitive pathways. This finding enhances understanding of hearing sensitivity and frequency selectivity.

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Area of Science:

  • Auditory Neuroscience
  • Cellular Electrophysiology

Background:

  • Cochlear outer hair cells perform mechanical-to-electrical and electrical-to-mechanical transduction.
  • Sound-induced vibration and extrinsic electrical currents activate hair cell motility, enhancing hearing sensitivity and frequency selectivity.

Purpose of the Study:

  • To investigate the pathway of extrinsic electrical currents entering cochlear hair cells.
  • To determine if currents enter through transduction channels or a capacitive shunt pathway.

Main Methods:

  • Recorded electrically evoked oto-acoustic emissions and cochlear microphonics.
  • Modulated transduction channels using low-frequency sound stimulation.
  • Measured changes in emissions and microphonics during sound stimulation.

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Main Results:

  • Electrically evoked oto-acoustic emissions were modulated by sound, directly proportional to cochlear microphonics.
  • Emissions increased when transduction channels were open and decreased when closed.
  • Results indicate extrinsic currents predominantly enter via the resistive pathway through transduction channels up to 12 kHz.

Conclusions:

  • Strongest evidence to date that electrically evoked emissions are generated by cochlear transduction mechanisms.
  • Extrinsic electrical currents enter cochlear hair cells primarily through transduction channels.
  • Findings may also be consistent with capacitive current modulation of motility dependent on channel state.