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Genetic variation in the east Midlands
1Department of Human Sciences, Loughborough University, UK.
Annals of Human Biology
|March 4, 1998
Summary
Genetic analysis of East Midlands blood donors reveals distinct population sub-groups. These genetic variations likely stem from historical settlement patterns of continental European groups, including Danes and Vikings.
Area of Science:
- Population Genetics
- Human Evolutionary Studies
- Genetic Anthropology
Background:
- The British Isles' gene pool is historically shaped by successive invasions and immigrations.
- Previous genetic surveys indicate a complex patchwork of gene pools across the region.
- Understanding regional genetic differentiation is key to tracing population history.
Purpose of the Study:
- To investigate genetic variations within the East Midlands population.
- To determine if regional genetic differences correlate with historical settlement patterns.
- To explore the genetic contribution of continental European populations, specifically Danes and Vikings.
Main Methods:
- Analysis of 18 conventional genetic systems (blood groups, serum proteins, red cell enzymes).
- Genotyping of 1117 blood donors from Derbyshire, Nottinghamshire, and Leicestershire.
- Geographical subdivision of samples based on place of residence.
Main Results:
- Significant genetic differences were identified among five geographically defined sub-populations within the East Midlands.
- The observed genetic patterns suggest localized ancestral origins.
- The data supports a model of historical population stratification.
Conclusions:
- The genetic landscape of the East Midlands reflects historical settlement dynamics.
- Danish and Viking migrations likely contributed to the observed genetic heterogeneity.
- Regional genetic studies are crucial for understanding the peopling of the British Isles.