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[The hemostatic system function of patients with severe forms of diphtheria]

V F Kirichuk, A A Shul'diakov, I A Zaĭtseva

    Terapevticheskii Arkhiv
    |January 1, 1997
    PubMed

    Insights

    Severe diphtheria infection causes significant hemostasis disorders, including blood clotting and fibrinolysis abnormalities. These impairments, indicative of disseminated intravascular coagulation (DIC) syndrome, correlate with disease severity.

    Area of Science:

    • Hematology
    • Infectious Diseases
    • Pathophysiology

    Background:

    • Diphtheria is a severe infectious disease with potential systemic complications.
    • Hemostatic system derangements are not well-characterized in severe diphtheria.

    Purpose of the Study:

    • To investigate hemostasis disorders in patients with severe diphtheria.
    • To correlate hemostatic abnormalities with clinical presentation and severity.

    Main Methods:

    • Prospective study of 100 patients with severe diphtheria.
    • Comprehensive analysis of procoagulant, anticoagulant, and fibrinolytic parameters.
    • Assessment of vascular antithrombogenic activity.

    Main Results:

    • Patients exhibited marked disorders in procoagulant, anticoagulant, and fibrinolytic pathways.
    • Abnormalities in vascular antithrombogenic activity were observed.
    • These hemostatic impairments correlated significantly with disease severity.

    Conclusions:

    • Severe diphtheria is associated with complex hemostasis derangements, consistent with disseminated intravascular coagulation (DIC) syndrome.
    • DIC presented either subclinically or as a hemorrhagic syndrome.
    • A hyper-hypocoagulant phase was common during the course of DIC in these patients.

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