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Distinct light microscopic changes in human immunodeficiency virus-associated nemaline myopathy
D M Feinberg1, A J Spiro, K M Weidenheim
1Department of Neurology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA.
Neurology
|March 4, 1998
Summary
Congenital nemaline myopathy (CNM) and adult-onset nemaline myopathy (AONM) share similar pathology. However, HIV-associated adult-onset nemaline myopathy (HAONM) presents unique microscopic features, including fiber degeneration.
Area of Science:
- Neurology
- Pathology
- Myology
Background:
- Nemaline myopathy is a group of inherited muscle disorders.
- It can manifest in infancy (congenital) or adulthood (adult-onset).
- Human immunodeficiency virus (HIV) infection can also be associated with adult-onset nemaline myopathy.
Purpose of the Study:
- To compare the histologic characteristics of congenital nemaline myopathy (CNM), adult-onset nemaline myopathy (AONM), and HIV-associated adult-onset nemaline myopathy (HAONM).
Main Methods:
- Histologic examination of muscle biopsies.
- Light microscopy analysis of muscle fibers.
Main Results:
- Congenital nemaline myopathy (CNM) and adult-onset nemaline myopathy (AONM) exhibited similar pathologic features.
- HIV-associated adult-onset nemaline myopathy (HAONM) displayed distinct microscopic findings.
- HAONM muscle fibers showed significant intrasarcoplasmic changes, such as small vacuoles and granular degeneration.
Conclusions:
- Histologic examination can differentiate HAONM from CNM and AONM.
- Distinctive pathological features in HAONM suggest a unique disease process potentially influenced by HIV infection.
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